EasyAtom — BLIND VALIDATION REPORT
Generado : 2026-05-28T15:00:45.968846
=================================================================
Corpus ciego   : 109 tripletes (0 treats para pares gold)
Pares gold     : 5
Hit@1          : 0/5
Hit@5          : 2/5
Hit@10         : 3/5
MRR            : 0.1400
L5 cadenas     : 5/5
L5 gene clave  : 4/5
Veredicto      : ⚠️  PARCIAL

DETALLE POR PAR:
-----------------------------------------------------------------
[PASS] metformin → type_2_diabetes
  Rank L2: 5  Rank L3: 5  Rank L2+L3: 5
  Mecanismo: Complex-I inhibition → energy stress → AMPK activation → reduced hepatic gluconeogenesis
  Gen clave: AMPK  |  Fuente: DrugBank DB00331; PMID 11778468
  L5 cadena: ======================================================== |   PROOF TRACE: metformin  ──►  type_2_dia
  L6 primes: ['INHIBITS', 'ASSOCIATES']
  L6 overlap con gold: 1/4

[PASS] imatinib → chronic_myeloid_leukemia
  Rank L2: 6  Rank L3: 6  Rank L2+L3: 6
  Mecanismo: BCR-ABL tyrosine kinase inhibition → apoptosis of CML blasts
  Gen clave: BCR_ABL  |  Fuente: DrugBank DB00619; PMID 11287973
  L5 cadena: ======================================================== |   PROOF TRACE: imatinib  ──►  chronic_mye
  L6 primes: ['INHIBITS', 'CAUSES', 'ASSOCIATES']
  L6 overlap con gold: 2/3

[PASS] levodopa → parkinsons_disease
  Rank L2: 3  Rank L3: 3  Rank L2+L3: 3
  Mecanismo: Dopamine precursor crosses BBB → DDC converts to dopamine → replenishes striatal deficit
  Gen clave: DDC  |  Fuente: DrugBank DB01235; PMID 5650719
  L5 cadena: ======================================================== |   PROOF TRACE: levodopa  ──►  parkinsons_
  L6 primes: ['REGULATES_DOWN', 'CAUSES']
  L6 overlap con gold: 1/4

[FAIL] atorvastatin → hypercholesterolemia
  Rank L2: None  Rank L3: None  Rank L2+L3: None
  Mecanismo: HMG-CoA reductase inhibition → mevalonate pathway block → reduced LDL production
  Gen clave: HMGCR  |  Fuente: DrugBank DB01076; PMID 7598563
  L5 cadena: ======================================================== |   PROOF TRACE: atorvastatin  ──►  hyperch
  L6 primes: ['INHIBITS', 'CAUSES']
  L6 overlap con gold: 2/3

[FAIL] aspirin → cardiovascular_disease
  Rank L2: None  Rank L3: None  Rank L2+L3: None
  Mecanismo: COX-1/2 inhibition → reduced TXA2 → antiplatelet effect → reduced thrombosis
  Gen clave: PTGS1  |  Fuente: DrugBank DB00945; PMID 10488934
  L5 cadena: ======================================================== |   PROOF TRACE: aspirin  ──►  cardiovascul
  L6 primes: ['INHIBITS', 'CAUSES']
  L6 overlap con gold: 2/3