{
  "timestamp": "2026-05-28T15:00:45.967541",
  "corpus_path": "C:\\Users\\ANRIV\\Desktop\\EasyHelpCare\\easyatom-engine\\blind_test_results\\20260528_150045\\corpus_blind.tsv",
  "n_triplets": 109,
  "n_pairs": 5,
  "hit1": 0,
  "hit5": 2,
  "hit10": 3,
  "mrr": 0.14,
  "chains_found": 5,
  "key_genes_found": 4,
  "verdict": "⚠️  PARCIAL",
  "results": [
    {
      "drug": "metformin",
      "disease": "type_2_diabetes",
      "rank_l2": 5,
      "hit10_l2": true,
      "top5_l2": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l2": 0.03,
      "mechanism": "Complex-I inhibition → energy stress → AMPK activation → reduced hepatic gluconeogenesis",
      "key_gene": "AMPK",
      "source": "DrugBank DB00331; PMID 11778468",
      "rank_l3": 5,
      "hit10_l3": true,
      "rank_best": 5,
      "hit10_best": true,
      "top5_l3": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l3": 0.02,
      "explain_chain": "======================================================== |   PROOF TRACE: metformin  ──►  type_2_diabetes |   (BFS en corpus, maxhops=3)",
      "explain_key_gene": true,
      "elapsed_l5": 0.02,
      "l6_primes": [
        "INHIBITS",
        "ASSOCIATES"
      ],
      "l6_mechanism": "direct_inhibitor",
      "l6_universality": 0.75,
      "l6_overlap": 1,
      "l6_lcs": 0.25,
      "l6_relations": [
        "inhibits",
        "associatedWith"
      ]
    },
    {
      "drug": "imatinib",
      "disease": "chronic_myeloid_leukemia",
      "rank_l2": 6,
      "hit10_l2": true,
      "top5_l2": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l2": 0.02,
      "mechanism": "BCR-ABL tyrosine kinase inhibition → apoptosis of CML blasts",
      "key_gene": "BCR_ABL",
      "source": "DrugBank DB00619; PMID 11287973",
      "rank_l3": 6,
      "hit10_l3": true,
      "rank_best": 6,
      "hit10_best": true,
      "top5_l3": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l3": 0.02,
      "explain_chain": "======================================================== |   PROOF TRACE: imatinib  ──►  chronic_myeloid_leukemia |   (BFS en corpus, maxhops=3)",
      "explain_key_gene": true,
      "elapsed_l5": 0.02,
      "l6_primes": [
        "INHIBITS",
        "CAUSES",
        "ASSOCIATES"
      ],
      "l6_mechanism": "pathology_direct_blocker",
      "l6_universality": 0.8167,
      "l6_overlap": 2,
      "l6_lcs": 0.6667,
      "l6_relations": [
        "inhibits",
        "causes",
        "associatedWith"
      ]
    },
    {
      "drug": "levodopa",
      "disease": "parkinsons_disease",
      "rank_l2": 3,
      "hit10_l2": true,
      "top5_l2": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l2": 0.02,
      "mechanism": "Dopamine precursor crosses BBB → DDC converts to dopamine → replenishes striatal deficit",
      "key_gene": "DDC",
      "source": "DrugBank DB01235; PMID 5650719",
      "rank_l3": 3,
      "hit10_l3": true,
      "rank_best": 3,
      "hit10_best": true,
      "top5_l3": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l3": 0.02,
      "explain_chain": "======================================================== |   PROOF TRACE: levodopa  ──►  parkinsons_disease |   (BFS en corpus, maxhops=3)",
      "explain_key_gene": false,
      "elapsed_l5": 0.02,
      "l6_primes": [
        "REGULATES_DOWN",
        "CAUSES"
      ],
      "l6_mechanism": "negative_regulator",
      "l6_universality": 0.85,
      "l6_overlap": 1,
      "l6_lcs": 0.25,
      "l6_relations": [
        "reduces",
        "causes"
      ]
    },
    {
      "drug": "atorvastatin",
      "disease": "hypercholesterolemia",
      "rank_l2": null,
      "hit10_l2": false,
      "top5_l2": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l2": 0.02,
      "mechanism": "HMG-CoA reductase inhibition → mevalonate pathway block → reduced LDL production",
      "key_gene": "HMGCR",
      "source": "DrugBank DB01076; PMID 7598563",
      "rank_l3": null,
      "hit10_l3": false,
      "rank_best": null,
      "hit10_best": false,
      "top5_l3": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l3": 0.02,
      "explain_chain": "======================================================== |   PROOF TRACE: atorvastatin  ──►  hypercholesterolemia |   (BFS en corpus, maxhops=3)",
      "explain_key_gene": true,
      "elapsed_l5": 0.02,
      "l6_primes": [
        "INHIBITS",
        "CAUSES"
      ],
      "l6_mechanism": "pathology_direct_blocker",
      "l6_universality": 0.975,
      "l6_overlap": 2,
      "l6_lcs": 0.6667,
      "l6_relations": [
        "inhibits",
        "causes"
      ]
    },
    {
      "drug": "aspirin",
      "disease": "cardiovascular_disease",
      "rank_l2": null,
      "hit10_l2": false,
      "top5_l2": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l2": 0.02,
      "mechanism": "COX-1/2 inhibition → reduced TXA2 → antiplatelet effect → reduced thrombosis",
      "key_gene": "PTGS1",
      "source": "DrugBank DB00945; PMID 10488934",
      "rank_l3": null,
      "hit10_l3": false,
      "rank_best": null,
      "hit10_best": false,
      "top5_l3": [
        "hematologic_cancer",
        "metabolic_syndrome",
        "parkinsons_disease",
        "hypertension",
        "type_2_diabetes"
      ],
      "elapsed_l3": 0.02,
      "explain_chain": "======================================================== |   PROOF TRACE: aspirin  ──►  cardiovascular_disease |   (BFS en corpus, maxhops=3)",
      "explain_key_gene": true,
      "elapsed_l5": 0.02,
      "l6_primes": [
        "INHIBITS",
        "CAUSES"
      ],
      "l6_mechanism": "pathology_direct_blocker",
      "l6_universality": 0.975,
      "l6_overlap": 2,
      "l6_lcs": 0.6667,
      "l6_relations": [
        "inhibits",
        "causes"
      ]
    }
  ]
}