[
  {
    "drug": "metformin",
    "disease": "type_2_diabetes",
    "mechanism": "Complex-I inhibition → energy stress → AMPK activation → reduced hepatic gluconeogenesis",
    "key_gene": "AMPK",
    "expected_primes": [
      "INHIBITS",
      "ACTIVATES",
      "REGULATES_DOWN",
      "CAUSES"
    ],
    "expected_chain": "metformin → AMPK → gluconeogenesis → type_2_diabetes",
    "expected_urgency": "HIGH",
    "source": "DrugBank DB00331; PMID 11778468"
  },
  {
    "drug": "imatinib",
    "disease": "chronic_myeloid_leukemia",
    "mechanism": "BCR-ABL tyrosine kinase inhibition → apoptosis of CML blasts",
    "key_gene": "BCR_ABL",
    "expected_primes": [
      "INHIBITS",
      "REGULATES_DOWN",
      "CAUSES"
    ],
    "expected_chain": "imatinib → BCR_ABL → uncontrolled_proliferation → chronic_myeloid_leukemia",
    "expected_urgency": "HIGH",
    "source": "DrugBank DB00619; PMID 11287973"
  },
  {
    "drug": "levodopa",
    "disease": "parkinsons_disease",
    "mechanism": "Dopamine precursor crosses BBB → DDC converts to dopamine → replenishes striatal deficit",
    "key_gene": "DDC",
    "expected_primes": [
      "TRANSPORTS",
      "TRANSFORMS",
      "ACTIVATES",
      "REGULATES_DOWN"
    ],
    "expected_chain": "levodopa → dopamine → dopamine_deficiency → parkinsons_disease",
    "expected_urgency": "HIGH",
    "source": "DrugBank DB01235; PMID 5650719"
  },
  {
    "drug": "atorvastatin",
    "disease": "hypercholesterolemia",
    "mechanism": "HMG-CoA reductase inhibition → mevalonate pathway block → reduced LDL production",
    "key_gene": "HMGCR",
    "expected_primes": [
      "INHIBITS",
      "REGULATES_DOWN",
      "CAUSES"
    ],
    "expected_chain": "atorvastatin → HMGCR → cholesterol_production → hypercholesterolemia",
    "expected_urgency": "MEDIUM",
    "source": "DrugBank DB01076; PMID 7598563"
  },
  {
    "drug": "aspirin",
    "disease": "cardiovascular_disease",
    "mechanism": "COX-1/2 inhibition → reduced TXA2 → antiplatelet effect → reduced thrombosis",
    "key_gene": "PTGS1",
    "expected_primes": [
      "INHIBITS",
      "REGULATES_DOWN",
      "CAUSES"
    ],
    "expected_chain": "aspirin → PTGS1 → thromboxane_synthesis → platelet_aggregation → cardiovascular_disease",
    "expected_urgency": "CRITICAL",
    "source": "DrugBank DB00945; PMID 10488934"
  }
]